
Can Magic Mushrooms Prevent Migraines?
HEMPEARTH – Small doses of magic mushrooms (microdoses) can help reduce the frequency and severity of migraine headaches.
One study found that administering psilocybin mushrooms to participants between the ages of 21 to 65 years (inclusive) reduced the number of migraine attacks compared to when they took a placebo .
One possible reason could be that psilocybin impacts serotonin 5-HT2A receptors, which are involved in regulating pain perception and releasing other neurotransmitters that mitigate pain signaling.
Researchers hypothesize that the activity of serotonin 5-HT2A receptors may be involved in developing and progressing migraines and cluster headaches .
It’s also possible that the therapeutic effects of psilocybin and psilocin in migraines may be related to their ability to reduce vascular inflammation, which may be a causative factor in migraine attacks.
Another theory is that psilocybin and psilocin alter brain activity in areas involved in pain perception and mood regulation.
What Exactly Are Migraines?

Migraines are a type of recurring headache that can leave you curled up in a dark room for days, trying to escape the throbbing pain and nausea.
They’re a complex neurological disorder characterized by moderate to severe pain, usually on one side of the head. They don’t present with visible symptoms, making it difficult for others to understand the severity of the condition.
How to Microdose Mushrooms for Migraines
Most anecdotal reports suggest that most people find relief with a dose that is slightly higher than a microdose, but lower than a recreational dose. This range is sometimes referred to as a mini-dose and usually falls somewhere in the range of 0.5 – 1 grams of dried psilocybin mushrooms.
Stay consistent.
The chart below describes how to use doses slightly larger than the typical microdose to manage migraine.

The Takeaway: Psilocybin For Migraine
The use of psilocybin (magic mushrooms) as a treatment for migraine sufferers is an area of ongoing research.
Studies have shown promising results in reducing migraine and cluster headache frequency and severity.
Many migraine sufferers are experimenting with their own micro-doses of mushrooms, with results that have helped to improve their conditions.
As the conversation around psychedelics and their therapeutic benefits continues to evolve, it may lead to new treatment options for those suffering from this condition and offer hope for a better quality of life.
