HEMPEARTH – 5-MeO-DMT And Toad Venom

5-MeO-DMT is a potent, fast-acting, and short-lasting psychedelic compound. Many people regard it as the world’s most powerful psychoactive substance. While it can provide people with profound and life-changing experiences, it is not as commonly used as other classic psychedelics, like psilocybin, LSD, and DMT.

5-MeO-DMT is a tryptamine psychedelic, which means it is a chemical derived from tryptophan, an essential amino acid. Other tryptamine psychedelics include psilocybin, psilocin, ibogaine, bufotenin, and DMT.

5-MeO-DMT differs from DMT (N,N-dimethyltryptamine), chemically speaking, in that the former is derived from the latter. You can see this based on 5-MeO-DMT’s full scientific name: 5-methoxy-N,N-dimethyltryptamine.

Where Can You Find 5-MeO-DMT?

5-MeO-DMT is a natural psychedelic compound. It often comes from many plant species and, most notably, one species of toad: Incilius avarius (or the Sonoran Desert Toad).

It is find the Sonoran Desert toad in arid and semiarid parts of the Sonoran Desert, in northern Mexico and the southwestern United States. Areas in the United States where it lives include the lower Colorado River and parts of California, New Mexico, and Arizona.

The Sonoran Desert toad secretes toxins (mostly steroids) from glands in its skin as a defense mechanism. The toad’s venom also contains the psychoactive substances 5-MeO-DMT and bufotenin (5-HO-DMT) .

It is common for people to use 5-MeO-DMT that has been extracted from this type of toad. This involves squeezing their glands and catching the spray on a piece of glass. When dried, the venom forms flaky crystals on the glass, which you can then collect for use. Vaporizing the dried venom destroys the toxins but not the 5-MeO-DMT.

The Effects Of 5-MeO-DMT

Mystical experiences with 5-MeO-DMT are common, including effects such as the following:

The 5-MeO-DMT experience lasts around 15 minutes. Depending on the dosage, the experience may be shorter or longer than this.

When smoked, the onset can occur within as little as five seconds. The come-up lasts 30-60 seconds. You reach the peak of the experience in 5-10 minutes, with the coming down stage lasting 10-20 minutes. After-effects can persist for 15-60 minutes.

The effects of 5-MeO-DMT come on strong and quickly, often with a loss of physical coordination and control. This is why it’s important to take the compound in the presence of a guide, as they will help ensure your physical safety.

Unlike DMT, 5-MeO-DMT does not often include a very visual experience. The experience involves more of an intense perspective shift, characterized by physical, emotional, and conceptual effects. During the onset, anxiety or excitement may occur. Intense emotions throughout are typical, ranging from extreme fear to euphoria.

It is common for people to experience traveling to a place that is purely white, with no visuals. Users may use terms such as “void” or “nothingness” to describe this place.

Therapeutic Uses

Many users of 5-MeO-DMT report that their experiences with the compound have transformed their lives for the better.

First, researchers have found that this potent psychedelic reliably induces mystical experiences. Other researchers have linked the therapeutic benefits of psilocybin to the compound’s ability to induce these types of experiences. By offering a deeply spiritual experience, 5-MeO-DMT may likewise be able to help people recover from mental health conditions like depression.

According to one study, a single experience with vaporizing 5-MeO-DMT can lead to reductions in depression, anxiety, and stress — as well as increases in life satisfaction and mindfulness — after the session and in the long term.

Also, the authors of the study state:

“Participants that experienced high levels of ego dissolution or oceanic boundlessness during the session displayed higher ratings of satisfaction with life and lower ratings of depression and stress.”

A separate study  found that the use of 5-MeO-DMT in a ceremonial group setting is associated with decreases in depression and anxiety.